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No. 5 Indiana vs No. 4 Ohio State: How to watch, odds, injuries, and predictions

The Hoosiers are looking to earn a monster win over the Buckeyes on Saturday afternoon.
ByConnor Grootenhuis
Indiana's Charlie Becker (80) celebrates his first down catch during the Indiana versus Ohio State Big Ten Championship football game at Lucas Oil Stadium on Saturday, Dec. 6, 2025.
Indiana's Charlie Becker (80) celebrates his first down catch during the Indiana versus Ohio State Big Ten Championship football game at Lucas Oil Stadium on Saturday, Dec. 6, 2025. | USA TODAY Network via Reuters Connect

Arguably the biggest game in Memorial Stadium history is slated for this Saturday when the Indiana Hoosiers host the Ohio State Buckeyes. It's officially a Top-5 matchup, as the Hoosiers are 6-0 and ranked No. 5 in the country while Ohio State is 5-1 and ranked No. 4 in this week's AP Top-25 Poll.

These teams have won each of the last two National Championships, and have built up quite the rivalry over the past two seasons. With so much on the line and plenty of fireworks in store, here is a look at all the crucial game information you need to know before Saturday rolls around.

How to watch Indiana vs Ohio State in Week 7

This highly-anticipated matchup between the Hoosiers and Buckeyes has been selected for FOX's Big Noon Kickoff, and thus, will start at Noon ET. The easiest way to watch the action unfold is via FOX, but the game can also be streamed on the FOX Sports App, FOX One, as well as Fubo TV.

The broadcast crew will consist of Gus Johnson on play-by-play, Joel Klatt as the color analyst, and Jenny Taft reporting from the sidelines.

Indiana vs Ohio State betting odds

On paper, this matchup is about as evenly-matched as it gets. However, professional oddsmakers are giving a slight edge to the Buckeyes. As of this publishing, Ohio State is favored by 3.5 points over Indiana on DraftKings Sportsbook. Here is a closer look at the full Indiana vs Ohio State betting odds for Week 7:

Moneyline
Ohio State (-180)
Indiana (+150)

Spread
Ohio State -3.5 (-108)
Indiana +3.5 (-112)

Total
Over 50.5 (-118)
Under 50.5 (-102)

Indiana is 6-0 on the season, but has gone just 1-5 against the spread. The Hoosiers' lone cover of the season came in Week 5 against Rutgers. On the other side, Ohio State is 5-1 straight up and 4-2 against the spread. The Over is 4-2 in Ohio State's six games, and 3-3 in Indiana's games so far this season.

Game odds refresh periodically and are subject to change.
If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

Indiana vs Ohio State all-time series history

As longtime Big Ten programs, the Hoosiers and Buckeyes are awfully familiar with one another. The two programs have met a total of 98 times on the gridiron, with Ohio State owning the all-time series lead 80-13-5. However, Indiana won the most recent matchup, which came in last December's Big Ten Championship Game. The Hoosiers prevailed by a score of 13-10 to earn the top seed in the College Football Playoff before winning it all.

RELATED: Big Ten Power Rankings heading into Week 7: Top spot on the line

Indiana Football Week 7 injury report

Indiana had a fairly clean injury report in Week 6 against Nebraska. Hopefully that continues in Week 7 against Ohio State. The Hoosiers are still without RB Khobie Martin, who suffered a broken forearm in Week 1 and hasn't returned since. DB Carson Williams, TE Andrew Barker, and WR Lebron Bond also missed the Nebraska game.

Official Big Ten availability reports for Week 7 have yet to be released, but it seems that the Hoosiers have an early advantage over the Buckeyes when it comes to health. Ohio State was down five starters, including three on the offensive line, this past weekend against Maryland. RG Austin Siereveld, WR Brandon Inniss, WR Devin McCuin, LB Christian Alliegro, and backup S Leroy Roker III, were all unavailable for OSU before the game, while starting LG Luke Montgomery went down with a lower body injury in the contest. Furthermore, staring RT Phillip Daniels hasn't played since the Texas game on Sept. 12.

Indiana vs Ohio State score prediction

Ohio State has looked borderline unstoppable since its 4th-quarter collapse against Texas in Week 2. Indiana has taken care of business in every game, but has shown some chinks in the armor. What’s most concerning is how completely the running game disappeared against Nebraska. That isn't going to fly against the Buckeyes. This has the makings of an instant classic and should come down to the wire. With revenge on their minds, the Buckeyes win a close one, 31-28.

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