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No. 4 Indiana vs. No. 20 USC: How to watch, odds, injuries, and predictions

The Hoosiers are back in action this Saturday with a huge matchup against the USC Trojans.
ByConnor Grootenhuis
Oct 31, 2026; Bloomington, Indiana, USA; Indiana Hoosiers wide receiver Charlie Becker (80) catches a pass in overtime for the game-winning touchdown against Minnesota Golden Gophers defensive back Aydan West (5) at Merchants Bank Field at Memorial Stadium. Mandatory Credit: Robert Goddin-Imagn Images
Oct 31, 2026; Bloomington, Indiana, USA; Indiana Hoosiers wide receiver Charlie Becker (80) catches a pass in overtime for the game-winning touchdown against Minnesota Golden Gophers defensive back Aydan West (5) at Merchants Bank Field at Memorial Stadium. Mandatory Credit: Robert Goddin-Imagn Images | IMAGN IMAGES via Reuters Connect

After a much-needed bye week, it is game week once again for Curt Cignetti and the Indiana Hoosiers. The Cream and Crimson have another big matchup on the docket, as the USC Trojans head to Bloomington for a pivotal showdown in Week 11.

Saturday's matchup between the Hoosiers and Trojans could have a huge impact on the Big Ten title race, as well as the College Football Playoff picture. Here is all of the crucial game information you need to know for Saturday's highly-anticipated tilt.

How to watch Indiana vs USC in Week 11

Kick-off between the Hoosiers and Trojans is set for 3:30 p.m. ET. The best way to watch the action unfold is via CBS. In addition, the game can also be streamed on Paramount+, and FuboTV. The broadcast crew will consist of Brad Nessler (play-by-play), Charles Davis (analyst), and Jenny Dell (sideline reporter).

Indiana vs USC betting odds

Professional oddsmakers are giving the edge to the Hoosiers in this Big Ten clash. Via DraftKings Sportsbook, Indiana is favored by 7.5 points over USC. Here is a closer look at the full Indiana vs USC betting odds:

Moneyline
USC (+230)
Indiana (-285)

Spread
USC +7.5 (-115)
Indiana -7.5 (-105)

Total
Over 49.5 (-115)
Under 49.5 (-105)

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Neither of these teams have been great at covering the spread this season. Indiana owns a record of 8-1 through nine games, but the Hoosiers have covered the spread just one time this season. That came back in Week 5 against Rutgers. On the other side, USC is 7-2 straight up and 3-6 against the spread. Both teams have also played in low-scoring games more often than not, as the under is 6-3 for Indiana and 5-4 for USC.

Game odds refresh periodically and are subject to change.
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Indiana vs USC all-time series history

The Hoosiers and Trojans aren't used to seeing each other on the gridiron. This will be just the fifth all-time meeting between these programs, and the first since USC joined the Big Ten prior to the 2024 season. USC has won all four previous matchups, with the most recent meeting resulting in a 28-7 win for USC back in 1982.

Indiana Football Week 11 injury report

While Indiana has been relatively healthy throughout the season, playing nine games in nine weeks is going to leave any team with some injuries. Official Big Ten availability reports for Week 11 have yet to be released. But names to keep an eye on for Indiana include QB Josh Hoover, CB AJ Harris, WR Davion Chandler and EDGE Kellan Wyatt. Hoover has been battling an undisclosed injury over the last few weeks, and was benched in favor of Grant Wilson at halftime of the Minnesota game. Harris left the Minnesota game, while Chandler and Wyatt were both unavailable against the Golden Gophers. Hopefully the bye week enabled the Hoosiers to rest up and get as close to full health as possible.

Indiana vs USC score prediction

The biggest question mark entering this matchup is who will be Indiana's starting quarterback. Will it be Josh Hoover? Or will it be Grant Wilson? The answer to that question has yet to be announced, but whoever gets the starting nod will have a big opportunity to make an impact and lead the Hoosiers in what is a pivotal Big Ten matchup.

Lincoln Riley finally got a signature win at USC last week. The Trojans took down the then-No. 2 ranked Ohio State Buckeyes 30-18. However, Ohio State was operating with a backup QB. Luke Fahey struggled to get anything going, and the Trojans controlled the game from start to finish.

With both teams coming off a bye, coaching matters even more in this one. In that case, the edge goes to Curt Cignetti and the Hoosiers. Riley has struggled in these big games at USC, and the Torjans have to travel across the country. Indiana has home field advantage, and has just found a way to win close games this season. I think that happens again in this one. Hoosiers win 27-21.

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