What to know for Indiana vs Oregon: Watch options, odds, injuries, and key storylines

No. 7 Indiana travels on the road to take on the No.3 ranked Oregon Ducks in a matchup of Big Ten title and CFP contenders
Sep 27, 2025; Iowa City, Iowa, USA; Indiana Hoosiers defensive back Louis Moore (7) reacts late in the game against the Iowa Hawkeyes at Kinnick Stadium. Mandatory Credit: Jeffrey Becker-Imagn Images
Sep 27, 2025; Iowa City, Iowa, USA; Indiana Hoosiers defensive back Louis Moore (7) reacts late in the game against the Iowa Hawkeyes at Kinnick Stadium. Mandatory Credit: Jeffrey Becker-Imagn Images | Jeffrey Becker-Imagn Images

The Oregon Ducks:

Oregon Ducks are coming off a bye week after an emotional double overtime win in Happy Valley against Penn State. The 34-31 win catapulted Oregon back in the top three of the Coaches and AP Polls and made quarterback Dante Moore a frontrunner for the Heisman Trophy.

Dante Moore leads the Ducks with 14 passing touchdowns to only 1 interception, 1210 passing yards and has a 74.6% completion percentage. Moore completed 29 of his 39 passes for 248 yards and 3 touchdowns against Penn State. Moore also added 35 yards on the ground on 10 carries. He also set a career high in completions and tied his career high in rush attempts.

Offensively, the Ducks average 46.6 points per game, which ranks 6th in the nation.

Freshman running back Dierre Hill Jr leads the team in rushing yards, with 270, while Dakorien Moore has a team-high 19 caught passes for 296 receiving yards, and three touchdowns.

Another superstar true freshman Dakorien Moore has a team-high 19 caught passes for 296 receiving yards, and three touchdowns.

On defensive the Ducks have playmakers all around led by edge rusher Matayo Uiagalelei. Dan Lanning's defense allows 12.2 points per game, which is 8th nationally. Oregon gives up 238.2 total yards per game, with 114.8 rushing and 123.4 passing yards per game.

Uiagalelei leads the Ducks in sacks, with 4.5 and senior linebacker Bryce Boettcher has a team-high 40 total tackles.

The Indiana Hoosiers:

Indiana led by head coach Curt Cignett and signal-caller Fernando Mendoza are off to a heavy and hot start to the season at 5-0 ranked No. 7 in the country.

The Hoosiers are coming off a emotional 20-15 road win over the Iowa Hawkeyes in Iowa City. In the previous week the defeated a top 25 opponent in Illinois 63-10.

Offensively, Indiana averages 47.8 points per game, which ranks 4th in the country. Defensively, they allow 9.6 points per game, which is 3rd overall in the nation. The Hoosiers averages 538.2 total yards per game, with 267.8 rushing yards and 270.4 passing yards per game. IU's defense led by safety Louis Moore allow 221.4 total yards per game, with 88 rushing and 133.4 passing yards per game.

Junior Fernando Mendoza leads the Hoosiers with 1208 passing yards and 73% completed passes. Roman Hemby leads the team in rushing yards, with 351, while Elijah Sarratt has a team-high 31 caught passes for 412 receiving yards, and six touchdowns.

On defense the well traveld veteran Louis Moore has a team-high 29 total tackles, 19 of them solo. Isaiah Jones leads the Hoosiers in sacks, with 3.5, while Louis Moore has three interceptions.

Where to watch Oregon vs. Indiana live:

Date: Saturday, Oct. 11 | Time: 3:30 p.m. ET
Location: Autzen Stadium in Eugene, Oregon
TV: CBS | Live stream: CBSSports.comCBS Sports App
Streaming on Paramount+ Premium

TV Brodcast Crew: Brad Nessler (Play-by-play), Gary Danielson (Analyst), Jenny Dell (Sideline reporter)

Betting odds and line:

The Line: Betting Odds: Oregon -7.5 — Over/Under: 53.5 (Indiana is +235 money line while Oregon is +290 ML per FanDuel

Injury Report (Oregon):

  • Daylen Austin (Questionable)
  • Kyler Kasper (Questionable)
  • Dorian Brew (Questionable)
  • Brayden Platt (Questionable)
  • Dillon Gresham (Out)
  • Trey McNutt (Out)
  • Evan Stewart (Out)

Injury Report (Indiana):

  • Bryson Baldwin (Questionable)
  • Bryson Bonds (Out)
  • Lee Beebe Jr (Out)
  • D'Angelo Ponds (Probable)
  • Tyler Morris (Out)

News and Notes:

  • Oregon leads all-time series vs. Indiana 2-1
  • The Ducks are 20-13 all-time and 9-3 at home when featured on “College GameDay.
  • Autzen Stadium will host a top-10 matchup for the eighth time in stadium history.
  • Oregon is one of only three teams (Indiana, Texas Tech) in the top 10 for both scoring offense and scoring defense.

Game Prediction:

Dan Lanning and the Ducks have not lost a home game since 2022. Will the Indiana Hoosiers be able to snap the nation's longest home winning streak?

Indiana versus Oregon is going to show me where exactly both teams are when it comes to covering up there weaknesses. Oregon's secondary will get test early and often but the RPO heavy offense of Indiana. The wide reciever room at Indiana will expose the shaky secondary of Oregon. Mendoza and the boys will put up points but they have their own weaknesses as well.

Up front Indiana will get bullied by Oregon, the Ducks are deeper, more talented and flat out going to push Indiana around up front but it just depends what they do with the opportunities. Dante Moore and his weapons may be too much to handle for the Hoosiers on Saturday afternoon.

I believe Indiana keeps it close and makes a statement early but Oregon wins this game at home and Dante Moore makes his name a household one after this performance. Oregon 34, Indiana 27.

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